Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation.
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چکیده
منابع مشابه
Atlas of Genetics and Cytogenetics in Oncology and Haematology EIF 2 AK 2 ( eukaryotic translation initiation factor 2 - alpha kinase 2 )
Key Promoter Elements: TATA-less (No TATA Box). 1. KCS (Kinase Conserved Sequence): Nucleotides 67 to -81 from the transcriptional start site. Required for basal expression utilizing Sp factors. Also required in combination with the ISRE for interferonstimulated expression (Kuhen and Samuel, 1997; Kuhen et al., 1998; Kuhen and Samuel, 1999; Ward and Samuel, 2002). 2. ISRE (Interferon-stimulated...
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Two factors have been isolated from wheat germ that enhance the ability of initiation factor 2(eIF-2) to form a ternary complex with GTP and Met-tRNAf. One of these factors, Co-eIF-2 beta, is a monomeric protein with a molecular weight of approximately 83,000 (Lax, S. R., Osterhout, J.J., and Ravel, J.M. (1982) J. Biol. Chem. 257, 8233-8237). The purification and properties of Co-eIF-2 alpha ar...
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The heterotrimeric eukaryotic initiation factor (eIF) 2 binds the initiator methionyl-tRNA in a GTP-dependent mode and delivers it to the 40 S ribosomal subunit. In the present study, we have identified amino acid residues in eIF2beta required for binding to eIF2gamma in yeast. Alteration of six residues in the central region of eIF2beta abolished this interaction, as determined by GST-pull dow...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.15.7215